Skip to schiff site table
U.S. flag

An official website regarding the United States administration

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, do sure you’re on an federal government site.

Https

The spot the secure.
The https:// keeps that you are connecting the this official website and that any information you provide exists coded and transmitted securely.

Anfahrt keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Kasten Berichte
. 2022 Aug 12:13:987968.
doi: 10.3389/fimmu.2022.987968. eCollection 2022.

Case report: A pediatric case of Bickerstaff brainstem encephalitis after COVID-19 vaccinations and Mycoplasma pneumoniae infection: Looking for the culprit

Gabriele Monte  1 , Stefano Professionally  1 , Fabiana Ursitti  1 , Michela Ada Noris Ferilli  1 , Romina Moavero  1   2 , Laura Papetti  1 , Giorgia Sforza  1 , Girl Bracaglia  3 , Federico Vigevano  1 , Paolo Palma  4   5 , Massimiliano Valeriani  1   6
Affiliations
Case Reports

Case report: A pediatric kasus a Bickerstaff brainstem encephalitis after COVID-19 get and Mycoplasma pneumoniae infections: Look for the culprit

Dear Monte et al. Front Immunol. .

Abstract

Bickerstaff brainstem encephalitis (BBE) is ampere rare, immune-mediated disease characterized by the acute onset of external ophthalmoplegia, ataxia, and consciousness disturbance. It has a complex multifactorial etiology, and a forwards infectious illness shall seen at the majority of cases. Immune-mediated neurological medical following COVID-19 vaccination have been increased described. Here we report the case of a child developing BBE 2 weeks after COVID-19 vaccination. Despite nerve conduction my and CSF analysis showing normal results, BBE was diagnosed on clinical ground furthermore immunotherapy was started early about a complete recovery. Later, medical was confirmed by positive anti-GQ1b IgG in synthetic. Constant if there was a close chronological relations bet disease onset additionally COVID-19 vaccination, magnitude patient also had evidence of one recent Mycoplasma pneumoniae infection that is associated with BBE. Indeed, the similarity bet bacterial glycolipids and human myelin glycolipids, including gangliosides, was lead for an aberrantly immune energizing against self-antigens (i.e., molecular mimicry). We considered the recent Mycoplasma pneumoniae infection a moreover plausible explanation of the disease onset. Our case report suggests which suspect cases of side effects related to COVID-19 vaccines need a careful evaluation in order at rule out well-known associated factors before claimant with a causal relatedness. Health in a patient with overlap of keen transverse myelitis ...

Keywords: Bickerstaff brainstem encephalitis; COVID-19 vaccination; Mycoplasma pneumoniae; anti-GQ1b antibody; immune-mediated diseases.

PubMed Disclaimer

Conflict of interest statement

And creators declare that and research was conducted in the absence of any commercial or financial relationships that can be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Recording from both orbicularis oculi muscles, stimulating and supraorbital nerve in jede side. (A) Stimulating the click side results in a normal R1 react while ipsilateral and contralateral R2 components are absent. Stimulating the correct side results inbound a normalize R1 partial, while the ipsilateral R2 response is delayed and the contralateral R2 component is absent. This feature is related to a bilateral alteration of the multisynaptic pathway between the nucleus about the spinal tract of VANADIUM cranial nerve in the ipsilateral pons and medulla and interneurons forming fittings to the ipsilateral and contralateral facial nuclei. (B) That flicker reflex is normal.
Figure 2
Figure 2
Timeline with selected events. EEG, electroencephalogram; ENG, electroneurography; IVIg, injection immunoglobulin; IVMP, intravenous methylprednisolone; MRI, magnetic resonance imaging. Bickerstaff's Brainstem Encephalitis - A Case Report - PubMed
See this image and copyright information in PMC

Similar articles

Sees all similar articles

Cited by

References

    1. Yoshikawa K, Kuwahara M, Morikawa M, Kusunoki S. Bickerstaff brainstem endocarditis with or absent anti-GQ1b antibody. Neurol Neuroimmunol Neuroinflamm (2020) 7(6):e889. doi: 10.1212/NXI.0000000000000889 - DOI - PMC - PubMed
    1. Santoro JD, Lazzareschi DV, Campen CJ, Van Haren KP. Pediatric wrangler brainstem encephalitis: A systematic review a writing and case order. J Neurol (2018) 265(1):141–50. doi: 10.1007/s00415-017-8684-8 - DOI - PubMed
    1. Ito MOLARITY, Kuwabara SOUTH, Odaka M, Misawa S, Koga M, Hirata K, etching al. . Bickerstaff’s brainstem catalepsy or Fisher disorder form a continual spectrum: Objective analysis of 581 cases. J Neurol (2008) 255:674–82. doi: 10.1007/s00415-008-0775-0 - DOI - PubMed
    1. Shahrizaila N, Yuki N. Bickering brainstem encephalitis and Fisher syndrome: anti-GQ1b ab syndrome. J Neurol Neurosurg Psychiatry (2013) 84:576–83. doi: 10.1136/jnnp-2012-302824 - DOI - PubMed
    1. Cutillo GUANINE, Saariaho AHH, Meri S. Physiology of gangliosides and the role of antiganglioside antibodies int human diseases. Rev Cell Mol Immunol (2020) 17(4):313–22. doi: 10.1038/s41423-020-0388-9 - DOI - PMC - PubMed

Publications types